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NSAIDs, or non-steroidal anti-inflammatory drugs, are commonly used medications to relieve pain, reduce inflammation, and reduce fever. They are also frequently used to treat symptoms such as headaches, nausea, menstrual cramps, colds, pain, and inflammation. NSAIDs play an important role in the treatment of various types of arthritis, such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, etc. They improve the quality of life of patients by reducing chronic pain, inflammation, and swelling. They do not slow the disease but reduce symptoms by inhibiting the cyclooxygenase (COX) enzyme, which is responsible for inflammation and pain.
Long-term use of NSAIDs carries many risks, including gastrointestinal issues, cardiovascular issues, and kidney damage. Thus, their use requires regular medical supervision, especially in patients with co-morbidities. Selective COX-2 inhibitors are sometimes preferred over traditional NSAIDs due to superior safety. Because of their ability to manage chronic symptoms and acute inflammation, NSAIDs in Bhubaneswar are widely used in rheumatoid arthritis, where they have been carefully managed to minimise side effects. The Department of Rheumatology at Manipal Hospitals, Bhubaneswar, has an experienced team of rheumatologists and doctors who provide the best treatments for various rheumatological disorders. Emphasis is placed on minimising complications and enhancing the treatment results by providing quality care services to their patients.
The prostaglandin chemicals in the body are responsible for causing inflammation and pain. The NSAIDs block the COX (COX-1 and COX-2) enzymes, which are involved in the production of prostaglandins. Therefore, NSAIDs alleviate pain and inflammation through this process.
The commonly used NSAID drugs are:
Celecoxib
Fenoprofen
Etodolac
Flurbiprofen
Diclofenac
Meloxicam
Ketorolac
Indomethacin
Naproxen
Oxaprozin
NSAIDs generally carry a warning due to their association with an increased risk of heart attack and stroke. Though the actual risk is unknown, people with heart disease, high cholesterol, diabetes, high blood pressure, and smoking are advised to check with their doctor before taking them. They are experts in evaluating its risk versus its benefits for your condition.
The common side effects offered by NSAIDs include:
Kidney issues
Swelling in the legs
Stomach issues like nausea, gas, stomach ulcers, pain, constipation, or diarrhoea
Dizziness
Headache
Rash
Cardiovascular issues
Liver damage
Increased risk of bleeding
Not everyone will experience these side effects, and NSAIDs are generally safe to consume if taken as directed by your doctor.
Yes, some people with asthma, nasal polyps, sinus issues, or other conditions may be sensitive to some NSAIDs. These drugs can cause allergies and may worsen breathing; thus, doctors generally advise you to avoid taking NSAIDs if you have asthma. However, some NSAIDs may be safe to use; discuss it with your doctor before consuming any NSAIDs for rheumatoid arthritis.
It's important to inform your doctor about all drugs and supplements you are taking before consuming NSAIDs for your condition. Also, inform about any underlying condition you may have, like heart failure, diabetes, lupus, asthma, ulcers, liver or kidney disease, high blood pressure, etc. Some NSAIDs may interact with cyclosporine, methotrexate, or blood thinners that you are already consuming. Your doctor must be informed about everything beforehand so that they can prescribe the right medication for your condition.
Although NSAIDs can help in managing chronic pain, inflammation, and swelling linked with rheumatoid arthritis, they do not slow down the disease. To prevent further joint damage, patients suffering from rheumatoid arthritis need to take other types of medications along with it.
The long-term use of NSAIDs is generally not recommended due to their higher risks of gastrointestinal and cardiovascular issues. If needed, should be taken under the complete guidance of your doctor. As a general instruction, one should not use NSAIDs for more than 3 days for fever and 10 days in case of pain, unless otherwise prescribed by your doctor.
Celecoxib NSAID is safe to use for the long term as it is designed to avoid gastrointestinal side effects.
To use NSAIDs safely, take the lowest effective dose for the shortest duration necessary, consume NSAIDs with food or milk to prevent stomach upset, avoid using multiple NSAIDs simultaneously, and refrain from drinking alcohol while using them. Always consult your healthcare provider if you have any underlying health conditions or are taking other medications.
NSAIDs are generally not recommended during pregnancy, particularly in the third trimester, due to potential risks for the mother and baby. Always consult a healthcare provider before using NSAIDs during pregnancy.
People with the following conditions should avoid taking NSAIDs or only take them after consultation with their doctor. These include:
Unmanaged diabetes
High blood pressure
Bleeding disorders
Kidney disease
Stomach ulcers
Crohn’s disease
History of heart attack or stroke
GERD disease
Heart failure
Bleeding disorders
If you experience any of these side effects after taking NSAIDs, contact your doctor right away. These include:
GI/urinary issues
Blood in urine
Cloudy urine
Blood or any material in vomit
Severe stomach pain
Unusual weight gain
Jaundice
Vision/hearing issues
Balance issues
Bad headache
Photosensitivity
Difficulty speaking
Allergic reactions
Chest pain
Wheezing
Itchy skin
Fluid retention
Flu-like symptoms
Bruising
Fatigue
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