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Intracavitary Chemotherapy involves administering drugs that fight cancer directly into body cavities such as the chest, abdomen, or bladder. This technique minimises systemic side effects while targeting cancer cells inside the cavity. To deliver medication to the tumour site at higher concentrations, a catheter must be inserted. This form of Chemotherapy is useful for localised tumours and is frequently used in conjunction with Radiotherapy or Surgery. Treatment choices are based on the patient's characteristics, cancer type, and stage. Close monitoring is necessary to control adverse effects.
By injecting medication directly into the body through a catheter, Intracavitary Chemotherapy minimises systemic side effects and maximises drug concentration at the tumour site to treat cancer. Compared to Systemic Chemotherapy, these Localised Chemotherapy procedures are more precise and have fewer adverse effects; nonetheless, they still require specialised expertise and close monitoring to ensure safety and maximal effectiveness.
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Intracavitary Chemotherapy involves administering drugs that fight cancer directly into body cavities such as the chest, abdomen, or bladder. This technique minimises systemic side effects while targeting cancer cells inside the cavity.
A specific type of Intraperitoneal Chemotherapy used to treat abdominal cancers following surgery is called Hyperthermic Intraperitoneal Chemotherapy (HIPEC). The chemotherapeutic solution is more effective when heated to 42–43°C because it increases medication penetration and tumour cell killing. The duration of this procedure is usually one to two hours, which enables the hot Chemotherapy to be distributed evenly throughout the abdominal cavity.
For some stomach cancers, HIPEC is frequently used in conjunction with other comprehensive therapy methods to enhance therapeutic results and lower the chance of cancer recurrence. Patients with peritoneal metastases can benefit from a synergistic strategy of treatment that combines surgery and HIPEC for optimal tumour control and possibly better survival.
Intraperitoneal Chemotherapy has demonstrated efficacy in the treatment of ovarian cancer, stomach cancer, appendiceal cancer (cancer of the appendix), and colorectal tumours (cancers of the colon and rectum). This technique directly delivers chemotherapy medications into the peritoneal cavity, maximising drug concentration at the tumour location and reducing systemic side effects.
The goal of Intraperitoneal Chemotherapy is to improve drug delivery to the abdominal cavity's malignant tissues directly, boosting tumour penetration and cell death while minimising systemic damage. By improving tissue perfusion and drug uptake, Hyperthermic Intraperitoneal Chemotherapy (HIPEC), which involves giving heated chemotherapy medications during surgery, might enhance therapeutic efficacy. Soon after surgery, Chemotherapy is administered intraperitoneally (EPIC) to target any cancer cells that may still be present and prevent recurrence.
HIPEC and EPIC represent intriguing choices for patients receiving therapy, as they have both been shown to be effective in increasing survival results for specific types of abdominal malignancies. These techniques optimise treatment approaches to fight peritoneal metastases and mark advances in customised cancer care.
During surgery, the catheter—which is attached to an access port—is placed into the abdominal cavity to administer chemotherapy medications directly. Depending on the intended area within the peritoneal cavity, surgeons place the access point either near the pelvis or the ribs. The port, easily accessible for medicine administration, stays beneath the skin.
During treatment sessions, chemotherapy medications are delivered into the port, whereupon they diffuse into the abdomen area via the catheter. This targeted delivery technique reduces systemic negative effects while increasing medicine concentration at the tumour site.
Intravesical Chemotherapy is a medical procedure in which a physician uses a soft, flexible catheter to directly inject chemotherapy drugs into the bladder. The drug interacts with the bladder lining when it is in the bladder for up to two hours. These medications help the bladder's lining separate from the layers of underlying tissue, which is then released from the bladder as urine. Because the medicine primarily targets cells within the bladder, this technique minimises systemic effects while enabling the formation of a new bladder lining free of cancer cells.
The bladder must hold very little urine and not fill up while the drug is being administered to maximise the effectiveness of the treatment. It is recommended that patients hold off on drinking anything for at least four hours before their appointment. They should also abstain from ingesting foods that contain caffeine, such as chocolate, tea, and coffee, as caffeine can increase the production of urine and stimulate the bladder.
Those who take water pills, or diuretics, regularly should wait to take them until after the treatment session to reduce the amount of urine that fills the bladder and to get the most out of the medication. Adhering to these recommendations guarantees the best possible circumstances for Intravesical Chemotherapy and increases its therapeutic advantages.
Intravesical Chemotherapy side effects usually go away a few days after treatment and are modest. These could include more frequent urination, burning when urinating, a faint reddish-pink tint to the urine, and the appearance of tiny scabs on bladder lining tissue. The majority of negative effects are caused by cystitis, or inflammation of the bladder.
Two to three litres of water a day can help reduce discomfort, and over-the-counter painkillers might help with the discomfort. To ensure timely care and assistance, patients should speak with their doctor about what to expect after the surgery and get in touch with them if any adverse effects last longer than 48 hours.
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