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Tau Clinic in Kolkata

Tau Clinics

Tau Clinic in Kolkata

Tau protein aggregation in the brain is a hallmark of tauopathies, a group of neurodegenerative disorders that include conditions like Frontotemporal Dementia (FTD), Cortico-basal Degeneration (CBD)/Cortico-basal Syndrome (CBS), and Progressive Supranuclear Palsy (PSP). This aggregation disrupts cellular activity, leading to neuronal loss and progressive degeneration of the nervous system.

Symptoms of tauopathies can be severe and diverse, ranging from impaired balance and coordination to difficulties in speech, movement, and cognitive function. The rate of disease progression varies among individuals, with some experiencing slow deterioration over the years and others deteriorating rapidly in a shorter timeframe.

Despite these differences, tauopathies pose significant challenges for patients, caregivers, and healthcare professionals alike, highlighting the urgent need for effective therapies and interventions. Ongoing research is focused on developing tailored medications to alleviate symptoms and delay disease progression by better understanding the underlying mechanisms of tau pathology.

Consult the specialists at our Tau Clinic in Kolkata if you need treatment for tauopathies. 

Book an appointment today at Manipal Hospitals Broadway to learn more about Tau Clinic in Kolkata. Consult with our experts today.

FAQ's

Movement and cognitive deficits such as limb rigidity, apraxia, and executive dysfunction are caused by CBD's primary effects on the cortex and basal ganglia. PSP is characterised by the degeneration of nerve cells in the brainstem and basal ganglia, which leads to defects in the eyes, movement, balance, cognition, and behaviour. 

Because the symptoms of these disorders overlap with those of other neurodegenerative diseases, a thorough clinical evaluation is necessary for an accurate diagnosis and appropriate care. Despite their rarity, studies on PSP and CBD are being conducted to better understand their underlying mechanisms and create new treatments that may lessen symptoms and decrease the course of the disease.
 

The build-up of tau protein in Corticobasal Degeneration (CBD) interferes with regular cell function, starting a series of actions that lead to the degeneration of brain tissue and eventual death of neurons. 

The exact mechanisms behind tau buildup and consequent cell death are still unknown, despite intensive research efforts. Scientists are examining a range of elements, such as cellular pathways, environmental factors, and genetic predispositions, to better understand the complex mechanisms behind CBD pathology and create focused therapies that would slow the advancement of the disease.
 

Impulsivity, lack of judgment, and socially unacceptable behaviour are further characteristics of individuals with behavioural-variant Frontotemporal Dementia (bvFTD). 

They might also exhibit stereotyped or repeated actions and have trouble with organising, planning, and making decisions because of executive function impairments. These symptoms necessitate specialist care and assistance since they can have a major negative impact on everyday functioning and interpersonal interactions.
 

The ability of the patient to articulate complicated sentences and their difficulty commencing speech are also assessed by doctors during the diagnostic phase of non-fluent variant primary progressive aphasia (nfvPPA). 

Different from other types of aphasia, people with nfvPPA usually still understand single words and simple concepts even when they struggle with grammar and fluency. Language exercises that emphasise particular deficiencies in phonological processing and grammatical structure may also be included in examinations.
 

Numerous prospective disease-modifying treatments are being actively investigated in research, including drugs with the goals of lowering tau or other pathogenic proteins linked to FTD. To address the underlying processes of FTD pathology, clinical trials are also looking into cutting-edge therapeutic techniques such as gene therapies, immunotherapies, and stem cell treatments. 

Even though there are not any effective treatments for FTD right now, research is still being done, so there is hope for future developments in treating and possibly decreasing the disease's course.
 

The average lifespan of 6.9 years following the start of clinical symptoms emphasises the progressive nature of PSP-RS and its profound effects on those who are afflicted. As the illness worsens, patients' and their carers' general quality of life frequently declines as a result of the loss of physical and cognitive abilities. To maximise care and support for people with PSP-RS, early identification and efficient treatment techniques are essential.
 

Early symptoms of Cortico-basal Syndrome (CBS) primarily involve motor and movement issues. These may include:

  • Asymmetrical rigidity or stiffness

  • Unilateral (one-sided) clumsiness or apraxia

  • Tremor

  • Postural instability

In addition to these motor symptoms, some individuals with CBS may also experience cognitive changes, such as difficulty with language or executive function. However, the motor symptoms are typically the initial and most prominent features of CBS.
 

Chronic Traumatic Encephalopathy (CTE) patients may also struggle with anger, impulse control, and personality changes. These symptoms frequently cause problems in interpersonal relationships and professional performance, having a significant negative influence on day-to-day functioning and quality of life. To maximise results and give impacted persons the right support and care, early detection and management of CTE are essential.
 

Neuroimaging examinations, such as MRI or PET scans, are used to detect distinctive brain changes associated with Alzheimer's disease (AD), such as hippocampal atrophy and amyloid plaque deposition, in addition to clinical symptoms and cognitive assessments. Cerebrospinal fluid (CSF) analysis and blood testing are two examples of biomarker analysis that can be used to help diagnose and track the course of an illness. 

Early detection makes it possible to intervene quickly and provide patients and their families with access to support services as well as pharmaceutical and non-pharmacological treatments.
 

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