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NSAIDs for Rheumatoid Arthritis Treatment Option in Broadway

NSAIDs

NSAIDs for Rheumatoid Arthritis Treatment Option in Broadway

One class of painkillers that adults use the most often is known as nonsteroidal anti-inflammatory drugs (NSAIDs). They are also used to treat systemic connective tissue illnesses and various forms of arthritis, including rheumatoid arthritis and osteoarthritis. NSAIDs may alleviate fever, oedema, and redness, which are signs of inflammation. NSAIDs are frequently prescribed to treat musculoskeletal diseases and to reduce pain and inflammation (swelling and redness). By inhibiting the cyclooxygenase (COX) enzymes, these drugs reduce the production of prostaglandins that contribute to inflammation.

NSAIDs are extremely beneficial in improving mobility and quality of life in patients with illnesses such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. However, possible adverse effects include gastrointestinal bleeding, cardiovascular risks, and renal impairment, which frequently limit their use. Extended use requires careful monitoring and may necessitate the use of COX-2 selective inhibitors, which have a reduced likelihood of causing gastrointestinal issues, or medications that protect the stomach.

Overall, NSAIDs are essential to rheumatologic therapy because they establish a balance between the requirement to control potential side effects and their effectiveness in relieving symptoms. If you are looking for NSAIDs for a Rheumatoid Arthritis treatment option in Broadway, do visit Manipal Hospitals located in Broadway, Kolkata. 

FAQ's

Doctors prescribe NSAIDs at different levels of dosage, depending on your condition.

  • Depending on how long the medication remains in your body, dosages might vary from once to four times per day. For example, if you have rheumatoid arthritis (RA), your doctor might prescribe greater doses of NSAIDs because RA frequently causes a lot of heat, swelling, redness, and stiffness in the joints.

  • For osteoarthritis and muscular injuries, lower doses might be sufficient because the joints usually show less swelling and, frequently, no warmth or redness.

  • No single NSAID offers a 100% success rate. Your physician may prescribe a variety of NSAIDs before determining which one is most effective for you.

NSAIDs that are frequently used in rheumatology include:

  • Ibuprofen: It is effective for reducing inflammation and mild to moderate pain

  • Naproxen: Suitable for chronic illnesses, it provides longer-lasting comfort

  • Diclofenac: For focused pain treatment, it comes in oral and topical formulations

  • Indomethacin: It is used frequently to treat acute gout episodes

  • Meloxicam: Reduced gastrointestinal adverse effects, preferential COX-2 inhibitory action

  • Celecoxib: Specific inhibitor of COX-2, lower risk of gastrointestinal issues

  • Etodolac: Expensive, but balances side effect profile with efficacy

  • Piroxicam: Used to treat chronic inflammatory disorders; long half-life

NSAIDs are mostly used to relieve pain, but your healthcare provider may not recommend them if: 

  • You have experienced severe adverse reactions after taking an analgesic or fever reducer.

  • You are more likely to experience gastrointestinal bleeding.

  • You suffer from stomach issues such as ulcerative colitis, Crohn's disease, heartburn, or GERD (gastro-oesophageal reflux disease, often known as chronic acid reflux).

  • You have a history of heart disease or stroke, or you have high blood pressure (particularly if it is poorly managed).

  • You either have renal illness or liver cirrhosis.

  • You have a bleeding disorder 

  • Your diabetes is out of control

  • You have been diagnosed with asthma

  • You are using a diuretic

Rheumatoid arthritis (RA) is an autoimmune disorder in which the body's immune system mistakenly attacks healthy joint tissue, resulting in symptoms such as pain, inflammation, stiffness, and damage to the joints. Pain from RA is commonly characterised as aching, throbbing, burning, and gnawing. It usually affects many joints, including the spine, and is usually symmetrical. By blocking COX enzymes (COX-1 and COX-2), which generate prostaglandins that promote inflammation, NSAIDs reduce the symptoms of RA. NSAIDs dramatically lower pain and inflammation by lowering prostaglandin levels. Some NSAIDs specifically inhibit COX-2 to lessen gastrointestinal adverse effects, even though most of them block both COX enzymes. For RA patients, this leads to significant pain reduction and a decreased inflammatory response.
 

They might trigger allergic reactions. Certain NSAIDs cause sensitivity in certain asthmatic individuals. Many medical professionals advise against taking specific NSAIDs by those who have asthma because the medications may make breathing worse. Those who have nasal polyps or sinus issues may be at higher risk. Make sure your doctor is aware of any asthma you may have. Some NSAIDs may be safe to take. 
 

Alternatives are frequently suggested first because NSAIDs can have adverse reactions. The most popular over-the-counter substitute for pain treatment is paracetamol, which is generally safe to use. If you experience muscle or joint pain in a specific area of your body, trying NSAID creams and gels topically can be beneficial first, as they typically have fewer side effects than pills or capsules. Depending on the nature of your health issue, your doctor can also suggest other medications and treatments for you. For instance, some people with joint or muscle pain may benefit from physiotherapy. 
 

If you have ulcers, high blood pressure, diabetes, lupus, asthma, renal or liver illness, heart failure, or high blood pressure, use NSAIDs with caution. All medications and supplements should be disclosed to your physician. NSAIDs and methotrexate, cyclosporine, lithium, or blood thinners may interact. 
 

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