.jpeg "Blood Cancer: Symptoms, Causes & Treatment | Dr. Divya Bansal | Manipal Hospital Delhi")
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Battling Thalassemia: Insights into Symptoms, Causes, and Treatment Options
Dr. Divya Bansal
5 Min Read
May 08, 2023
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Hematology And Bone Marrow Transplant
Bone Marrow Transplantation in Delhi
When a two-year-old girl from a neighbouring country received bone marrow in our country, it became national news. Most children with Mucopolysaccharidosis (a condition that impacts the eye and brain function) and other rare conditions find it difficult to survive beyond their teenage years. Bone Marrow Transplant is a ray of hope for patients with Hematologic diseases (disorders of blood and blood-forming organs). Bone marrow Transplant (BMT) treats a wide range of hematologic diseases. It is an effective treatment for Aplastic Anemia, Leukemia and other blood cancers, Sickle-Cell disease, Thalassemia, and other blood disorders. Manipal Hospitals is the best Bone Marrow Transplant hospital in Delhi which offers the leading facilities for treating hematologic diseases. The process involves destroying all existing bone marrow with radiation or chemotherapy before injecting new cells into the body. The new cells will grow in place of the old ones destroyed during the process. BMT improves disease-free survival in Acute Myeloid Leukaemia (AML), Aplastic Anaemia, and Thalassemia Major
OUR STORY
Know About Us
Why Manipal?
Manipal Hospital is the best Bone Marrow Transplant hospital in Delhi. We have state of art infrastructure and a team of doctors and nurses to treat malignant and non-malignant blood-related problems. Our facilities include sophisticated laboratories, blood transfusion services, and a radiation oncology unit.
We are known for treating patients with rare blood-related diseases. Our BMT centre has a 5-bed unit with a HEPA filter and positive pressure ventilation. We also offer Cryopreservation, Apheresis stem cell products and Irradiation of blood products (to prevent transfusion-associated Graft-Versus-Host disease).
What is Haematology?
Haematology deals with blood and blood-producing tissue. Haematologists specialise in blood disorders, such as Anaemia, Thalassaemia and Leukaemia. They can also help diagnose and treat conditions related to the bone marrow, stem cells or platelets.
How Does a Bone Marrow Transplant Work?
Bone Marrow is a soft, fatty tissue found inside bones. It contains blood cells produced in the bone marrow and then released into the bloodstream.
A Bone Marrow Transplant replaces a patient's blood-forming cells with healthy cells from a donor. This Procedure can treat many types of cancer and other blood diseases. The Bone Marrow Transplant involves removing bone marrow from the patient and then giving it to the patient after collecting the transplanted cells from the donor. The patient gets the collected cells back, where they grow into new blood cells.
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The first step of this process is finding a donor with a matching tissue type.
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The second step is preparing the body for the transplant by taking drugs that suppress or destroy the immune system.
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Finally, after all of this preparation is complete, the doctor will give high doses of chemotherapy or radiation therapy before giving the new blood-forming cells so that there are no remaining diseased cells left inside them before injecting them back into the body, where they will grow into healthy new cells!
Bone Marrow or Stem Cell Transplant Types
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Autologous Bone Marrow Transplant involves harvesting bone marrow cells from the patient's body and re-injecting them into the bloodstream. This process can treat certain cancer forms, such as Leukaemia, and fight diseases like Sickle Cell Anemia and Thalassemia.
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Allogeneic Bone Marrow Transplant replaces the diseased bone marrow with healthy, functioning bone marrow. The patient's diseased marrow is destroyed with chemotherapy and radiation therapy before the new marrow is transplanted. Then another person's healthy bone marrow cells are given through an infusion into a vein in the arm (transfusion).
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Related Donor Transplant is when the donor is usually a patient's close relative. A sibling is often a close match, while an identical twin is a perfect match.
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A Half-Matched Family Member Donor Transplant is when no option for a close-match transplant is available. This type of donor includes biological parents, siblings, or children.
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Matched Unrelated Donor Transplant is when there are no blood relatives who are a match for the transplant, the transplant team may look into an international registry to find a donor that matches.
Diseases and Conditions that Need Bone Marrow Transplant
Bone Marrow Transplant helps in the treatment of the following conditions.
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Acute Myeloid Leukemia/ Acute Lymphoblastic Leukemia
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Hodgkin's Lymphoma
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Non-Hodgkin's Lymphoma
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Multiple Myeloma
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Myelodysplastic Syndrome
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Non-Cancerous Conditions
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Neuroblastoma
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POEMS Syndrome
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Germ Cell Tumours
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Aplastic Anaemia
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Thalassemia Major
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Multiple Sclerosis
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Primary Immune Deficiency Syndrome
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Haematological and Storage Disorders
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Immunodeficiency Disorders
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Plasma Cell Disorders
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Primary Amyloidosis
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Inborn Errors of Metabolism
Who is eligible for Bone Marrow Transplant?
A Bone Marrow Transplant treats patients suffering from haematological conditions, such as Leukaemia. The surgeon monitors the patient's condition and determines whether they are eligible for a bone marrow transplant. The eligibility criteria include the following:
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The patient suffers from a haematological condition for which a bone marrow transplant is the only option.
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The doctor monitors the patient's condition, including liver function, kidney function, Karnofsky performance score (performance score for cancer patients), age, and mental health.
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An HCT comorbidity index determines the severity and prevalence of comorbidities in various organs.
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Psychological issues
Who is an eligible donor?
An eligible donor should have the following:
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HLA match to determine whether or not the donor has a blood type that matches the patient's blood type.
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Free of any heart, lung, or kidney disease.
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A healthy assessment from the doctor
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Free of HIV or any blood condition.
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Free of any cancer.
What happens after the Procedure?
The patient remains in isolation to reduce the infection risk. Allogeneic transplantation requires at least three months, while an Autologous transplant needs a month for the initial recovery.
The patient should adopt the following lifestyle changes after Bone Marrow Transplant:
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Avoid food with infection risk and eat a balanced diet.
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Avoid going to crowded places.
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Avoid getting in touch with sick people.
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Avoid alcohol and smoking.
Contact our surgeons if you require Bone Marrow Transplantation in Delhi.
FAQ's
The main risk is that the body will reject the donor cells and cause an infection in the area where the cells were injected (called Graft- versus -Host Disease). Other complications include blood clots, Pneumonia or bladder infections, and low blood counts like Anaemia and Neutropenia (low white blood cell counts). Consult our hospital if you require Bone Marrow Transplantation in Delhi.
Finding a suitable donor for a bone marrow transplant can be challenging, but it is not impossible! Here are some tips for finding a donor:
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Talk to the doctor about the options and understand what kind of donor is needed and how to find one.
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We are the best Bone Marrow Transplant hospital in Delhi. We help patients find a donor and help donors to volunteer their bone marrow.
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Talk to family members and friends about registering as donors. A close relative match is most suitable.
The return to everyday life depends on the patient's situation. It can take anywhere from a few months to a year, as recovery is different for everyone. Usually, patients resume work after three months and gradually move to moderate workouts and everyday activities. Consult us if you require Bone Marrow Transplantation in Delhi.
Blood irradiation uses ionising radiation to kill blood-borne pathogens and prevent blood-borne diseases. Ionising radiation changes the structure of molecules. This process can cause damage to DNA, which can lead to cancer. For blood irradiation to work, it must have a high radiation dose, meaning that patients will reduce their total white blood cell count.
Bone marrow is a spongy tissue inside your bones that makes blood cells. A bone marrow transplant is a procedure to replace the blood-forming cells (stem cells). First, the patient receives chemotherapy, radiation, or both, to kill cancer cells and healthy cells in the bone marrow. Then, the patient receives new stem cells through an IV. The new stem cells make healthy blood cells.
It is estimated that the overall survival rate for 20 years after hematopoietic cell transplantation is 80.4%. Patients who do have the recurrence of the original disease and survive for 5 years after transplant have a high chance of survival for the next 15 years. To get bone marrow transplantation in Delhi, visit the best hospital.
Generally, the hospital stay is around 21-30 days depending upon the type of surgery, speed of recovery, underlying medical condition, and surgical complications. The patient should visit the hospital for a routine check-up. To know more, arrive at the bone marrow transplantation hospital in Delhi.
The patient is taken care of by a multidisciplinary team of experts along with trained nurses. The vital parameters of the patient are under constant monitoring, and the recovery process is evaluated routinely. Get the best bone marrow transplantation in Delhi.
We have an experienced team of doctors and nurses, who are well-trained in various complications post-transplant. Get the best bone marrow transplantation treatment in Delhi.
On average, hospital stay for BMT is between 20-35 days and requires further follow up, the duration depends on the type of BMT and indication.
Yes, it helps to prevent Transfusion-Associated Graft-Versus-Host Disease (TGVHD), a rare but fatal complication. The condition arises due to lymphocytes from the transfused blood component attacking the recipient's tissues.
Book an appointment with one of our specialists today if you require Bone Marrow Transplantation in Delhi
