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Best Doctors for Cushing Syndrome Treatment in Dhakuria

Cushing Syndrome

Best Cushing Syndrome Treatment Doctors in Dhakuria

Cushing syndrome, also known as hypercortisolism, is a rare but serious disorder characterised by prolonged exposure to high levels of cortisol, a hormone produced by the adrenal glands. Cortisol plays a crucial role in regulating various bodily functions, including metabolism, immune response, and stress management. However, excessive levels of cortisol can lead to a range of health problems.

Cushing syndrome can arise from various causes, including excessive cortisol production, long-term use of corticosteroid medications, pituitary gland tumours, and ectopic ACTH production. Early diagnosis and management are crucial. At our hospital, we offer comprehensive diagnostic and treatment services to address Cushing syndrome effectively, improving patients' quality of life.

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FAQ's

The symptoms of Cushing syndrome include:

  • Weight gain, particularly in the abdominal area, face (moon face), and upper back (buffalo hump)
  • Fatigue and muscle weakness
  • Elevated blood pressure
  • Skin changes, such as thinning, easy bruising, and stretch marks (striae)
  • Increased thirst and urination
  • Mood swings, irritability, and anxiety
  • Irregular or absent menstrual periods (in women)
  • Decreased libido and erectile dysfunction (in men)
  • Osteoporosis and increased risk of fractures due to weakened bones
  • Cognitive impairment and memory difficulties

If you suspect you have any of these symptoms, consult a healthcare professional for a proper evaluation and diagnosis.

Individuals at risk of developing Cushing syndrome include those:

  • Using corticosteroid medications long-term
  • Affected by pituitary or adrenal tumours
  • With ectopic ACTH production
  • Women, especially those aged 20-50
  • With a family history of related conditions
  • Dealing with obesity
  • Having certain medical conditions, like PCOS or diabetes

Ectopic ACTH refers to the production of adrenocorticotropic hormone (ACTH) outside of the pituitary gland. Normally, the pituitary gland in the brain secretes ACTH, which stimulates the adrenal glands to produce cortisol. However, in cases of ectopic ACTH syndrome, tumours located outside of the pituitary gland - such as in the lungs, pancreas, or other organs - produce ACTH in excess. This excessive ACTH secretion leads to increased cortisol production by the adrenal glands, contributing to the development of Cushing syndrome.

Cushing syndrome is diagnosed through a series of tests and evaluations. The diagnostic process involves:

  • Medical History and Physical Examination: A healthcare professional will review your medical history and perform a physical exam to look for signs like weight gain, stretch marks, bruises, and other physical changes associated with Cushing syndrome.

  • Laboratory Tests:

    • 24-hour Urinary Free Cortisol Test: This test involves collecting urine over 24 hours to measure cortisol levels.

    • Salivary Cortisol Measurement: Measures cortisol levels in a saliva sample collected late at night.

    • Low Dose Dexamethasone Suppression Test: This test involves taking dexamethasone and testing cortisol levels the next morning.

    • Dexamethasone-CRH Test: This test helps differentiate various causes of high cortisol levels.

  • Imaging Tests:

    • MRI or CT Scans: These scans can help locate tumours in the adrenal or pituitary glands that may be causing Cushing syndrome.

  • Confirmation of Excessive Cortisol Secretion:

    • If excessive cortisol secretion is confirmed, further tests are done to determine the source of the excess cortisol, which could be from an adrenal gland tumour, ACTH-producing tumours, or pituitary ACTH-producing adenoma.

The treatment options available for Cushing syndrome include:

Surgery

  • If Cushing syndrome is caused by a tumour, such as an adrenal adenoma or pituitary adenoma, surgical removal of the tumour may be necessary. 

Medication

  • Cortisol-Reducing Medicines: Medications can be prescribed to reduce cortisol levels in the body.

  • Hormone-Inhibiting Medicines: Certain medications target different levels of hormone production and can be used when surgery is not an option or has failed.

Radiation Therapy

  • Radiation Therapy may be used as a treatment option, especially when surgery is not successful or feasible.

Chemotherapy

  • Chemotherapy may be considered for certain cases, particularly when dealing with cancerous tumours causing Cushing syndrome.

Bilateral Adrenalectomy

  • In cases of persistent hypercortisolism, Bilateral Adrenalectomy (removal of both adrenal glands) can be a second-line treatment option, but it requires careful evaluation due to the permanent hormonal changes it causes.

  • These treatment options aim to normalise hormone levels, control the disease in the long term, and address any comorbidities associated with Cushing syndrome

The prognosis for Cushing syndrome depends on the underlying cause and the effectiveness of treatment. In some cases, successful treatment can lead to the resolution of symptoms and normalisation of cortisol levels. However, in other cases, particularly those caused by adrenal or pituitary tumours, lifelong management and monitoring may be necessary.

Untreated Cushing syndrome can lead to serious health complications, including high blood pressure, diabetes, osteoporosis, cardiovascular disease, increased susceptibility to infections, and mental health issues such as depression or cognitive impairment. Prompt diagnosis and treatment are essential to minimise the risk of complications.

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