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A cancer form called a Gastrointestinal Stromal Tumour (GIST) starts in the digestive tract, and GISTs often develop in the small intestine and stomach. A GIST is a cell growth that is believed to develop from a certain kind of nerve cell. The lining of the digestive organs contains these unique nerve cells, which contribute to how the body processes food. GISTs may occur at any age but are far more prevalent in adults and uncommon in children. Most GISTs have an unknown origin, and a small percentage are brought on by genes inherited from parents.
Symptoms
Small GISTs may not show any symptoms and may develop slowly enough so that they initially pose a minimal threat. There may be symptoms when a GIST develops. They might consist of:
A growth you can feel in your abdomen
Abdominal pain
Fatigue
Nausea
Vomiting
Abdominal discomfort that worsens after eating
Not having a hunger feeling when you usually would
Having a sense of fullness even after consuming little food
Dark-coloured stools induced by digestive system bleeding
Diagnosis
Your doctor may start questioning your problems and general health to diagnose a GIST. Additionally, you may require further testing to detect the tumour if your symptoms raise the possibility that you have a GIST. These tests might consist of:
Imaging Tests
Your medical team uses imaging tests to locate your tumour and determine its size. To know more, Consult with our experts.
Upper Endoscopy
A thin, long tube (endoscope) with a view on the end is used for this exam. The tube passes down the neck and through the mouth. This test scans the oesophagus, stomach, and first segment of the small intestine on the inside.
Endoscopic Ultrasound (EUS)
The endoscope used in this examination also has an ultrasonic probe at the tip. The ultrasound probe takes photos of the tumour and calculates its size using sound waves.
Fine-Needle Aspiration Biopsy
his test takes a tumour tissue sample to test in a lab. This test is similar to EUS, except the endoscope's tip has a tiny, hollow needle. EUS locates the tumour, and the needle for lab testing collects small quantities of tissue. Sometimes the findings are unclear because the needle can't reach enough cells. Surgery could be required to get the sample.
5. Biopsy at a Laboratory
Your tumour biopsy sample is sent to a lab for analysis. In a lab, experts examine the cells to determine if they are cancer cells.
Treatment
Targeted therapy and surgery are often used to treat GIST. Certain GISTs don't need immediate treatment, and small GISTs without symptoms may not require therapy.
Surgery
The purpose of surgery is to remove the GIST altogether. It's often the initial way to proceed for GISTs that haven't progressed to other body regions. Your cancer will determine the kind of surgery you have. Surgeons may often do minimally invasive surgery to reach the GIST. As a result, many smaller abdominal incisions are made rather than a single big one before the surgical instruments are inserted.
Targeted Drug Therapy
Targeted drug therapies concentrate on certain compounds found in cancer cells. These medications aim to block the tyrosine kinase enzyme, which promotes the growth of cancer cells in GISTs. Imatinib(Gleevec) is often used to start targeted medication treatment for GISTs. If imatinib is ineffective or stops functioning, you may be prescribed other targeted medications. Visit our cancer care hospital in Hebbal, Bangalore for the best treatment.
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