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Dr. Subrata Saha

Consultant - Medical Oncology

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Reviewed by

Dr. Subrata Saha

Consultant - Medical Oncology

Manipal Hospitals, Salt Lake

Understanding The Cancer Management And Cancer Cure

Reviewed by:

Dr. Subrata Saha

Posted On: Feb 09, 2023
blogs read 7 Min Read
Cancer Management and Cancer Cure

Cancer causes uncontrollable cell division. This can result in tumours, immune system damage, and other potentially fatal impairments. It can be traumatic and terrifying to learn that you have cancer. Being prepared and taking charge of your health might help you feel more empowered, from diagnosis through recovery.

What is Cancer?

Cancer is a disease in which certain cells in the body grow uncontrollably and spread to other parts of the body. Cancer can develop almost anywhere in the human body, which contains trillions of cells. The process of cell division can sometimes break down, allowing abnormal or damaged cells to grow and multiply when they should not. This results in tumour formation, which can be cancerous or benign.

Cancerous tumours invade nearby tissues and can travel to distant locations in the body to form new tumours (a process called metastasis). Cancerous tumours are also known as malignant tumours. Many cancers grow into solid tumors, but blood cancers like leukaemia do not. Benign tumours do not spread or invade nearby tissues. They rarely recur after removal.

What are the Differences between Cancer Cells and Normal Cells?

According to cancer management and cancer cure case studies, cells normally follow the instructions provided by genes. Genes define the rules that cells must follow, such as when to begin and stop growing. Cancerous cells disregard the rules that normal cells follow, such as:

  • Normal cells divide and multiply in a controlled manner, while cancer cells multiply in an uncontrolled manner.

  • Normal cells have been processed to die (known as apoptosis), while cancer cells usually ignore such directions.

  • Normal cells do not spread to other parts of the body and are stationary, while cancer cells are able to move around.

  • Normal cells do not grow as rapidly as cancer cells do.

  • Cancer cells try to avoid being identified by the immune system. Damaged or abnormal cells are normally eliminated by the immune system.

Cancer Development in the Body:

Cancer develops when one or more genes mutate and produce cancerous cells. Cancer clusters, or tumours, are formed by these cells. Cancerous cells may break free from tumours and travel to other parts of your body via your lymphatic system or bloodstream (this is referred to as metastasis by doctors).

Cause

Cancer has many causes, some of which are preventable. Some of the common causes include:

  • Genetics

  • Tobacco and other related narcotics.

  • Alcohol

  • Exposure to unnatural radiation like UV rays for extended periods of time.

  • Exposure to some chemicals has a longer duration.

  • Diet and lifestyle.

  • Infections

  • Unhealthy environment.

Risk Factors

Medical oncologist in saltlake, kolkata has pointed out some of the following risk factors:

  • Smoking and tobacco consumption.

  • Diet: Consumption of high-fat foods increases the chances of cancer.

  • Environment: Toxin exposure, such as from asbestos, pesticides, and radon in the environment, will increase cancer risk.

  • Radiation Exposure: exposure to UV light from the sun increases the chances of developing skin cancer.

  • Hormone Replacement Therapy: People who use hormone replacement therapy are more likely to develop breast cancer and endometrial cancer.

Types of Cancer:

More than a hundred different types of cancer are distinguished by abnormal cell growth. Following are a few examples of cancer:

  • Carcinoma

It is the most common type of cancer, affecting the epithelial cells that line internal organs and the skin. The common manifestations include lung cancer, skin cancer, pancreatic cancer, and ovarian cancer. Carcinomas are distinguished by the cells that they affect: 

  • Adenocarcinoma

  • Squamous carcinoma

  • Basal cell carcinoma

  • Transitional cell carcinoma

  • Sarcoma

It begins within the bones and soft tissues, including fat tissues, cartilages, blood vessels, lymph, and other supporting tissues like tendons and ligaments.

  • Leukemia

It is also known as "blood cancer," and it affects the bone marrow tissues and produces blood. It is one of the most lethal forms of cancer.

  • Lymphoma

It is a type of cancer that affects the immune system's lymphocytes in the lymph nodes.

  • Melanoma

It is a type of skin cancer that attacks melanin, the pigment that gives skin colour.

  • Myeloma

Myeloma attacks plasma cells, which are part of the immune system. The affected plasma cells, known as myeloma cells, divide in the bone marrow, resulting in multiple bone tumours.

  • CNS Cancers

These cancers begin in the brain and spinal cord.

Signs and Symptoms: 

Cancer is a complex disease. Cancer can exist for years without causing symptoms. Other times, cancer may cause noticeable symptoms that worsen quickly. Early cancer symptoms include:

  • Unexplained weight loss.

  • Chronic tiredness.

  • Persistent pain.

  • Fever that occurs primarily at night.

  • Changes in the skin, mainly moles changing the shape and size or developing new moles.

Cancer, if left untreated, may cause more symptoms, such as:

  • Easier bleeding or bruises.

  • Bumpy or lumpy areas under your skin that persist.

  • Difficulty in breathing.

  • Difficulty in swallowing.

Stages of Cancer:

Stage describes how far along the disease is, including the size of the tumour and whether it has spread to other body areas.

  • Stage 0

Cancer cells have not yet invaded nearby tissues despite being present.

  • Stages I, II, and III

More cases equal a disease that is more advanced in terms of tumour size and invasion of nearby organs and tissues.

  • Metastasis

Cancer spreads to other body parts.

Diagnosis of Cancer:

The doctors perform a physical examination for patients undergoing a cancer diagnosis. The tests performed for cancer diagnosis at cancer care hospital in saltlake, kolkata include the following:

Blood Tests Include:

  • Complete blood count (CBC): It counts and measures the blood cells.

  • Tumour markers: These are released by the cancer cells or by normal cells in response to cancer cells.

  • Blood protein tests: Electrophoresis is carried out to measure immunoglobulins, and the immune system shows a reaction against some cancers by releasing these immunoglobulins.

  • Circulating tumour cell tests: Tumour cell activity can be tracked by this test.

Imaging Tests such as:

  • Computed tomography (CT) scan: It helps identify the location of tumour cells and their impact on other body parts.

  • X-rays: These images show the bones and soft tissues.

  • Positron emission test (PET) scan: It provides images of body organs and tissues and helps in identifying early signs of cancer.

  • Ultrasound: It provides images of inside portions of the body by utilising high-intensity sound waves.

  • Magnetic resonance imaging (MRI): It creates a computerised image of organs and other inside regions of the body by using a large magnet and radio waves.

  • Iodine meta-iodobenzylguanidine (MIGB): This is a nuclear imaging test that helps in diagnosing cancer.

  • Genetic Testing

If someone has an inherited form of cancer, the doctor could advise genetic testing.

  • Biopsies

They are performed in order to collect cells, tissue, fluid, or growths for microscopic examination. Following are some different types of biopsies used for diagnosing cancer. 

  • Needle biopsy.

  • CT-guided biopsy.

  • Ultrasound-guided biopsy.

  • Bone biopsy.

  • Bone marrow biopsy.

  • Liver biopsy.

  • Kidney biopsy.

  • Aspiration biopsy.

  • Prostate biopsy.

  • Skin biopsy.

  • Surgical biopsy.

New Developments in Diagnostics:

Researchers are utilising technologies like artificial intelligence, DNA sequencing, precision oncology, and others to improve disease therapy and diagnostics.

  • Genetic Testing

Doctors can find mutations that put a person at high risk for specific types of cancer by looking at their unique DNA. They can then be put on prevention-focused screening and treatment procedures.

  • Targeted Immunotherapie

Doctors can find mutations that put a person at high risk for specific types of cancer by looking at their unique DNA. They can then be put on prevention-focused screening and treatment procedures.

  • Artificial Intelligence in Fighting Cancer

An AI-based risk profile can assist in screening for common malignancies like breast cancer, resulting in an early diagnosis. In situations where imaging specialists would not be present, AI technology can be utilised to examine X-rays and spot malignancies.

  • Liquid and Synthetic Biopsies

Blood samples can be examined for indications of cancer using liquid biopsies, an easier and less intrusive procedure. Another breakthrough that can encourage cancer cells to surface in the early stages of the disease is synthetic biopsies.

Treatment:

Innovative research has resulted in the development of new medications and treatment technologies. Treatments are typically prescribed by doctors based on the type of cancer, its stage at diagnosis, and the individual's overall health.

The Revolution in Cancer Treatment

According to reports of the cancer care hospital in saltlake, Kolkata, one in every two people will be diagnosed with cancer during their lifetime, resulting in a greater-than-ever demand for new effective therapies. Our growing understanding of cancer allows us to create new technologies that combat various mechanisms of tumour survival while sparing healthy cells to reduce side effects. Despite significant advances in both treatment and diagnosis in recent years, there is still a pressing need for novel strategies to reduce disease burden.

Thanks to numerous technological advancements that have improved how we identify, recognise, comprehend, and treat cancer, what previously appeared unattainable in the field of cancer research is now a reality. It may be possible to speed the fight against this disease by continuing to research and employ these technologies.

CRISPR, artificial intelligence, telehealth, the Infinium Assay, cryo-electron microscopy, and robotic surgery are all helping in the fight against cancer. Following are some treatment approaches for cancer:

  • Surgery

Surgery is also used to make an initial cancer diagnosis. A solid lump or tumour can be surgically removed and the tissues examined for cancer under a microscope. This is a diagnostic and therapeutic application of surgery. The majority of cancer patients will require surgery. If the cancer has not spread to other organs or tissues, surgery can greatly improve the chances of survival. 

  • Surgical Procedures

The two main types of cancer surgery are minimally invasive surgery and open surgery. Researchers are looking forward to new methods of surgery. Other types of cancer surgery include: 

  • Cryosurgery

  • Electro surgery

  • Laser surgery

  • Mohs surgery

  • Laparoscopic surgery

  • Robotic surgery

  • Natural orifice surgery

  • Endoscopy

  • Embolization

  • Pleuroscopy

  • Chemotherapy

It is a type of aggressive cancer treatment in which toxic medications are used to kill rapidly dividing cancer cells. It can be used to reduce the size of a tumour or the number of cells in your body, lowering the chances of cancer spreading. Some chemotherapy drugs affect the normal cells, showing some side effects. But not all anti-cancer drugs cause side effects. Some may be fairly selective for cancer cells only.

  • Radiation Therapy

In radiation therapy, cancer cells are killed by strong, focused radiation beams. Brachytherapy refers to radiation therapy administered within the body, whereas external beam radiation refers to radiation therapy administered outside the body.

  • Targeted Therapy

It involves the use of drugs to interfere with specific molecules that help cancer cells grow and survive. Genetic testing may reveal a specific candidate for this type of therapy. It may be determined by the type of cancer the patient has as well as the genetic mutations and molecular characteristics of their tumour.

  • Immunotherapy

This includes therapy with molecules known as monoclonal antibodies, which specifically target cancer while sparing healthy cells. In this, the body’s own immune system is used as defence to attack the cancer cells.

  • Hormone Therapy

This therapy removes or blocks hormones that fuel certain cancers, preventing cancer cells from growing. It is mainly used to treat cancers that use hormones to grow and spread, such as breast cancer and prostate cancer.

  • Stem Cell Transplant (Peripheral Blood, Bone Marrow, and Cord Blood Transplant)

This treatment helps repair diseased bone marrow with healthy stem cells. These transplants let the doctors treat cancer with stronger chemotherapy dosages. To cure leukaemia, stem cell transplants are frequently employed.

  • Photodynamic Therapy

In order to kill cancer cells, this therapy uses special medications called photosensitizing agents in combination with laser light. Only after light activation do the medications begin to operate.

  • Clinical Trials

They study novel cancer therapies. This could involve evaluating the potency of medications that the Food and Drug Administration (FDA) has already approved but for other uses. Additionally, testing different medicines may be part of it. For those who might not have had the amount of success they desired with conventional treatments, clinical trials can present an additional option. This treatment may occasionally be given without charge.

Cancer Prevention:

  • Avoiding known cancer-causing behaviours, such as smoking, radiation exposure, etc.

  • Lifestyle changes.

  • A low-fat, high-fibre, fruit-and-vegetable diet lowers the risk of certain cancers.

  • Vaccination for hepatitis B and human papillomavirus.

  • Frequent screenings for individuals who are more at risk, such as those who have a family history of cancer or have been exposed to ionising radiation.

  • A yearly full-body check-up for prevention.

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