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Ankylosing spondylitis (AS) is a chronic inflammatory illness that causes axial arthritis. It typically causes inflammatory low back discomfort early in the disease's course, with eventual significant limitation of spinal movement owing to structural abnormalities that eventually lead to spinal fusion. AS is the archetype of a diverse collection of arthritides within the rheumatic disorders originally classified as seronegative spondyloarthropathies but now often referred to as spondyloarthritis (SpA). In addition to axial arthritis, AS can cause peripheral arthritis, enthesitis, and uveitis, all of which are symptoms of SpA.
Causes
Spondyloarthritis is hypothesised to occur due to the combination of hereditary and environmental factors. Many spondyloarthritis patients have HLA-B27, a gene variation that regulates immune responses. No one gene, however, influences whether a person develops spondyloarthritis. Many more genetic variations that enhance illness risk have been found. Reactive arthritis is a kind of spondyloarthritis that occurs following a urinary tract infection or an episode of infectious diarrhoea caused by certain bacteria. Bacteria may play a role in ankylosing spondylitis and other spondyloarthritis variations, generally without creating overt infection. Inflammatory bowel disease patients can develop spondyloarthritis, implying that certain disease processes are shared. We currently do not know enough about the causes of spondyloarthritis to be able to avoid it.
Symptoms
Spondyloarthritis symptoms vary between people but may include the following,
Chronic low back pain.
Stiffness in the back.
Back pain and stiffness usually worsen at night and become better with activity.
Fatigue.
Joint swelling that causes pain.
Fingers or toes that resemble sausages Heel discomfort
Psoriasis skin and nail changes
Inflammation of the eyes (uveitis)
Many people with spondyloarthritis have a first-degree relative with spondyloarthritis or a condition associated with spondyloarthritis (ankylosing spondylitis, psoriatic arthritis, psoriasis, Crohn's disease, ulcerative colitis, uveitis).
Diagnosis
Typically, your doctor will begin by reviewing your medical history and performing a complete physical exam. The following tests and methods may be used to provide spondyloarthritis treatment in Sarjapur Road,
Blood tests can detect your HLA-B27 status and assess inflammatory markers.
Imaging examinations are performed to check for signs of inflammation and to rule out other possible explanations of the patient's symptoms. The type of imaging investigation (X-ray, ultrasound, or MRI) will be determined by the patient's symptoms.
Treatment
Spondyloarthritis therapy is determined by the kind of spondyloarthritis and the severity of the sickness. Among the drugs available for treatment are the following,
In individuals with peripheral arthritis, nonsteroidal anti-inflammatory medications (NSAIDs) and disease-modifying anti-rheumatic medicines (DMARDs) such as methotrexate or sulfasalazine may be utilised. These drugs are ineffective in treating spinal inflammation.
Biologics are second-line medications used to treat people with spinal inflammation (ankylosing spondylitis). TNF and IL-17A inhibitors, as well as other biologics, are utilised to treat peripheral spondyloarthritis. This field's drug development activities are continuing.
Physical therapy is an essential aspect of long-term spinal illness care.
Consult with the doctors at Manipal Hospitals now.
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