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The blood cells are made in the bone marrow of humans. If malformed or less in number, these cells could not function correctly. This could be due to various diseases or conditions. In these cases, a bone marrow transplant (BMT) becomes valuable. In a BMT, unhealthy or abnormal blood-forming cells (stem cells) in the bone marrow are replaced with healthy ones. It is a non-surgical procedure as the new cells are injected into the bloodstream through an intravenous (IV) catheter or tube, similar to how blood or medicines are injected. Also known as hematopoietic stem cell transplant, this procedure is required for patients whose bone marrow stops working and does not produce enough healthy blood cells. BMT is usually done either after radiation and chemotherapy or both in children who need this procedure for whatever reason. It can be blood cancer (ALL, AML, JMML, CML, etc.), lymphoma (Hodgkin or Non-Hodgkin), aplastic anaemia, bone marrow failure syndromes (like Fanconi or Diamond Blackfan Anemia), primary immunodeficiency diseases (like SCID, WAS), hemoglobinopathy (like Thalassemia or Sickle Cells Disease), metabolic diseases like (Adrenoleukodystrophy, Hurler syndrome) or others.
Manipal Hospital is the leading name in Healthcare for Bone Marrow Transplants. With a dynamic team of complex transplant experience, we offer the best of clinical excellence. Our transplant physicians are skilled in handling complex cases of young patients. With state-of-the-art medical technologies and a team of clinical excellence at par with world standards, we offer holistic care to BMT patients of all ages. This centre of excellence is supported by many other centres, which are as follows.
Department of Hemato-pathology and Molecular Genetics
Department of transfusion medicine (Immunohematology), capable of T cells depletion procedures
Department of Infectious Diseases
Dedicated Pediatric Critical Care team
Specialized Pediatric Transplant Daycares with HEPA-filter facilities
Team of experienced experts, including doctors and nurses
Manipal Hospitals provides the best treatment for Pediatric Bone Marrow Transplants. Book an appointment with our expert consultants today best-multispeciality hospital in Bangalore.
Depending on the source of stem cells, there are two types of bone marrow transplants:
Autologous transplant (cells sourced from the patient themself)
Allogeneic transplant (cells are sourced from a donor, related or unrelated)
When we don’t have a matched related or unrelated donor for an allogeneic bone marrow transplant, we do 50% HLA-matched bone marrow transplants, popularly called haploidentical BMT. At Manipal Hospitals, Delhi, we offer BMT procedures for both types. Consult with our team of bone marrow transplant specialists in Bangalore.
Treatment and Procedure
At Manipal Hospitals, Delhi, we have a team of proficient transplant physicians who provide excellent treatment and care for young patients who need a bone marrow transplant. We offer all types of bone marrow transplants:
When the stem cells for transplant come from the patient themself, it is called an autologous transplant. The stem cells are collected from the bone marrow or blood of the patient well before the transplant starts and then reused once chemo-immunotherapy (conditioning) for that transplant has been given. The autologous transplant helps by killing the cancer cells but retaining the body’s ability to produce the required blood cells and fight infections. Few experts call it high-dose chemotherapy followed by stem cell rescue.
When the stem cells for transplant come from a healthy donor (related or unrelated), it is called an allogeneic transplant. In cases of leukaemia or other malignancies, the new stem cells from a donor destroy the cancer cells and remain in the body throughout life, thereby treating cancer. The donor's blood proteins, human leukocyte antigens (HLA), must match with patients for a donation to be possible. Earlier, HLA was supposed to be 100% matching for a transplant possibility. Still, nowadays, in related donors (donors from the family), even if HLA is just 50% matched, we can do an allogeneic BMT, popularly called a haploidentical bone marrow transplant. This option is for those patients who cannot find a suitable donor (in the family or the registries); we offer haploidentical bone marrow transplants. These transplants can be T-replete (post-transplant cyclophosphamide) or T-deplete (TCR αβ and B depleted) bone marrow transplants, depending upon the disease and condition of the patient. In haploidentical BMT, the donor is usually a family member (sibling or either of the parent), and we very rarely need someone like a sibling of a parent or even grandparents. The option of a haploidentical bone marrow transplant almost always ensures that they can be given one if a patient needs an allogeneic transplant. With time, the results of haploidentical BMT have matured and are almost the same as that of other allogeneic transplants.
Umbilical Cord Blood Transplant
This is offered very rarely nowadays. In this procedure, umbilical cord blood is used to harvest stem cells for transplantation. The blood that remains in the umbilical cord after a baby is born is known as umbilical cord blood. Modern facilities allow the storage of umbilical cord cells and blood. They can be used for tiny babies or patients, particularly in metabolic diseases.
Manipal Hospitals, Delhi, offers the best bone marrow transplant services under the guidance of Dr. Satyendra Katewa. He is a Paediatric Hematology, Oncology & Bone Marrow Transplant consultant at Manipal Hospitals, Delhi. He is a pioneer in establishing haploidentical and more advanced allogeneic bone marrow transplants for the children of India. Visit our top bone marrow transplant hospital in Bangalore today for the best treatment.
