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Kidney transplantation is the surgical approach of placing a healthy kidney from a deceased donor into an individual whose kidney does not function properly. The kidneys are two bean-shaped organs located on each side of the rib cage. It aims at the filtration and removal of waste, minerals, and fluid from the blood by urination. Kidney transplantation is integrated as the last choice for patients with end-stage renal disease (ESRD). It is mainly carried out to help patients suffering from chronic kidney disease and end-stage kidney failure.
The condition occurs when the kidney is not capable of filtering the waste, which results in the accumulation of harmful waste and fluid in the body. It further increases blood pressure and results in kidney failure, mainly known as an end-stage renal disease (ESRD). ESRD usually occurs when the kidneys have lost 90% of their ability to function normally. Some of the major causes of ESRD include:
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Diabetes
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Chronic, uncontrollable blood pressure
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Chronic glomerulonephritis causes inflammation and scarring of the tiny filters in the kidneys.
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Polycystic kidney disease.
Hence, in such conditions, the individual having ESRD needs to have waste material removed from the bloodstream either through dialysis or kidney transplantation for survival.
Delayed kidney transplantation can lead to major complications in kidney transplantation and has a number of long-term consequences. It may require increasing use of marginal kidneys during a time of kidney shortage. This condition usually occurs due to growth in the specifications regarding the acceptable donors, involving marginal and older donors along with other recipients who are more inclined towards delayed transplantation. Consult with our Nephrologist in Vijayawada to know more about the transplant.
The administration of several medications affects the progression of malignancies following dialysis. Hence, several guidelines have revealed the fact that delaying kidney transplantation among patients with end-stage kidney disease (ESKD) and malignancy increases the risk of death. The malignancies cause variations in the progression and mortality risk while delaying kidney transplantation among the patients with ESKD that eventually show an association with an increasing risk of death. Hence, the decision to delay kidney transplantation should involve a comparison of the mortality risk from any malignancy to the chances of mortality associated with remaining dialysis-dependent condition.
Benefits of Delaying Kidney Transplantation
When compared to those who have already received transplantation, those who delay their transplantation have a much lower long-term risk of death. Several studies have revealed the fact that the risk of death immediately after transplantation is higher in transplant recipients when compared with those who have delayed the transplantation. Delaying kidney transplantation has resulted in a better survival rate when continued with the treatment of dialysis. It is also effective in counselling the patients who have accepted the high-risk donor kidneys and developing strategies for reducing the morbidity and mortality related to the lower quality of the kidney.
Delayed kidney transplantation is associated with improved patient and renal allograft survival. It decreases the chances of a longer stay in the hospital for the patients. Also, there is a decreased chance of getting any type of infection when transplantation is delayed as the patient has a less chance of being admitted to the hospital. Delaying kidney transplantation helps to protect the kidney from injury, as transplantation requires the integration of surgical procedures. A decreased incidence of delayed graft function may be evolving and improvement in the patient’s survival can be observed. Vist our Kidney transplant Hospital in Vijayawada for the best treatment.
Risk of delaying Kidney Transplantation
The delay in kidney transplantation increases the chances of death among the patients while waiting for the transplant. It further causes major complications and thus creates an environment where a higher fraction of transplantations are performed with such complexities. A delay in transplantation means the patient is entirely dependent upon the continuity of dialysis treatment. The occurrence of kidney-related diseases also causes other comorbidities such as diabetes mellitus, hypertension, and cardiovascular diseases. The induction of continued dialysis among the patients blunts the immune response, and the delay in transplantation eventually decreases the immunity among the patients, which results in an increased risk of infection. The presence of various comorbidities in patients may increase the likelihood of cancer development due to a suppressed immune system.
Consultant - Nephrology And Renal Transplant Physician
Manipal Hospitals, Vijayawada
