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What is Thalassemia?
Thalassemia is a blood disorder and is an inherited disease. The condition affects the production of normal haemoglobin in your body. A red blood cell contains a protein called haemoglobin. By transporting oxygen throughout your body, red blood cells nourish other cells in your body.
In people with Thalassemia, fewer red blood cells and fewer healthy haemoglobin proteins are produced by their bone marrow. A person with Anaemia has a low number of red blood cells. For your body to function correctly and make energy, your cells need enough red blood cells to deliver oxygen to all the tissues and organs in your body.
Signs and Symptoms
Thalassemia comes in several forms. Your symptoms and signs will vary depending on the severity and type of your disease.
There are several signs and symptoms associated with Thalassemia, including,
Feeling fatigued
Lack of strength
Yellowish or pale skin
Deformities of the facial bones
Slow growth
Swelling in the abdomen
A dark urine colour
Symptoms of Thalassemia may appear at birth for some babies. For others, they emerge during their first two years of life. Thalassemia symptoms do not occur in all people with one affected haemoglobin gene.
Causes of Thalassemia
Blood cells that carry oxygen throughout your body, called red blood cells, are mutated by Thalassemia due to mutations in their DNA. Mutations cause thalassemia to be passed down from parents to their children.
Mutations can affect alpha and beta chains, which make up haemoglobin molecules. It is possible to have either alpha- or beta-thalassemia when the production of either is reduced in Thalassemia.
Alpha-thalassemia is determined by how many gene mutations your parents passed on to you. Your Thalassemia will be more severe if you have more mutated genes.
Beta-thalassemia is categorised as mild, moderate, or severe, depending on which part of the haemoglobin molecule is affected.
Treatment procedures
The traits of Thalassemia are not treated in mild cases.
Patients in thalassemia clinic in Yeshwanthpur, Bangalore with moderate to severe Thalassemia may benefit from the following treatments,
Regular Blood Transfusions
Frequent blood transfusions are often needed in patients with more severe forms of Thalassemia. Your heart, liver, and other organs can suffer damage from blood transfusions over time.
Therapy Involving Chelation
Excess iron in the blood is removed with this treatment. Regular transfusions can lead to an accumulation of iron. There is also the possibility of thalassemia patients who do not receive regular transfusions developing excess iron. Your health depends on removing excess iron.
Deferasirox (Exjade, Jadenu) or deferiprone (Ferriprox) are oral medications that help your body get rid of excess iron. A needle is also used to administer deferoxamine (Desferal).
Cell Stem Transplant
Stem cell transplants are also called bone marrow transplants. Blood transfusions and drugs overloaded with iron can be eliminated for children with severe Thalassemia.
A compatible donor, usually a sibling, infuses stem cells into the patient.
Is it possible to cure Thalassemia?
The best chance to cure Thalassemia is to obtain bone marrow from a compatible sibling. There is no suitable sibling donor available for most people with Thalassemia. There is also a risk of severe complications from a bone marrow transplant, including death.
Identify whether you are a candidate for a thalassemia transplant by meeting with a specialist. You have a better chance of a cure when choosing a hospital that performs bone marrow transplants regularly. Book an appointment at Manipal Hospitals now.
Experience world-class healthcare at Manipal Hospitals. Our expert team of doctors and state-of-the-art facilities ensure personalized and advanced treatments. Take the first step towards wellness. Book an appointment today.
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